Neuropeptide RFRP-1 (81-92) – Neuroscience Peptides

Neuropeptides are small signaling molecules produced and released by neurons engaged in many physiological functions. Indeed,neuropeptides act on neural substrates such as G protein-coupled receptors (GPCRs),tyrosine-kinase receptors,insuline-like peptides and also ion channels. Actions of neuropeptides result in slow-onset,long-lasting modulation of synaptic transmission. Pro-FMRFamide-related neuropeptide VF also called neuropeptide VF precursor are expressed in neurons in mediobasal hypothalamus. Neuropeptide VF precursor is a propeptide which is cleaved in three others peptide: Neuropeptide RFRP-1,RFRP-2 and RFRP-3. Neuropeptide RFRP-1 play a role in the negative regulation of gonadotropin synthesis and secretion. Neuropeptide RFRP-1 is an agonist of the NPFF1 and NPFF2 receptors. In rats,neuropeptide RFRP-1 increases prolactin release. Neuropeptide RFRP-1 (81-92) MPHSFANLPLRF-NH2 is a part of neuropeptide RFRP-1 and is used to study NPFF receptors.

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