Peptide synthesis method development

Develop and optimize peptide synthesis methods

IC-PEPTIDEoffers to develop synthesis methods for difficult peptides or large-scale peptide productions. There are many possible parameters to work with and try to improve peptide synthesis methods, such as number of couplings, use of pseudoproline, heating, etc. IC-PEPTIDE's peptide synthesis method development service consists of testing different synthesis conditions, identifying the best ones and confirming results on a pilot scale.

Additionally, IC-PEPTIDE has developed in-silico predictive tools to assess the feasibility of a synthesis and adapt the process. Depending on several parameters such as the identification of difficult sequence portions, hydrophobicity, and composition in amino acids, the predictive tool allows one to anticipate possible difficulties inherent in peptide synthesis and therefore find the best conditions.

Objectives are to find conditions with lowest raw material consumption, highest yield and impurities that can be easily purified to make the purification step easier.